If you happen to be facing a villain with a lot of treachery cards, like Thanos—-this ally can potentially shut down a villain’s entire encounter phase for 1 turn(assuming you drew 2 treachery cards and took 2 damage to Negasonic both times). It’s not a forced interrupt so it lets you choose how much treachery you’re willing to tolerate. That extra encounter card is not worth it though if you’re not setup first, but then again at 4 cost you wouldn’t be playing her otherwise.

You can avoid chump blocking with her since playing the Pool’ aspect means you’re going to have access to health regeneration and then can ready with the upgrade Sticktoitivness. Just defend, heal the 2 damage(assuming you take any if you have a hero with a naturally high defense), ready up and then you’re good to go. It’s an interesting pseudo-protection strategy.

Side Note: In fact, I had great success implementing it with heroes who have access to the aerial keyword, like Thor. With the player side-scheme Superpower Specialization and Soaring Acrobatics you can get +2 basic defense without ever having to “go green” which is pretty amazing actually. Imagine running Limitless Stamina(x3), in a deck with +2 defense and an upgrade that also lets you ready. At that point you’ll never have to flip down and just be punishing the competition then after turn.