Silk: Web Shield

Do your best best get Armored Vest + 4 tucked cards from the Villain's encounter set to potentially block for 8 DEF each turn when blocking with the Spider Reflexes upgrade

After a big DEF block, use Stop Hitting Yourself for massive retaliatory damage + electrostatic Armor for 1 extra damage

Get out all of Silk's hero upgrades to make the best use out of her stats

Use Web Allies to help you out while you are building yourself up