With Great Mutant Power

For Boomguy's Great Responsibility challenge.

Pretty simple.

She-Hulk Smash.

X-Men Thwart.

One Way or Another for card draw.

All the confuses let you flip down for more card draw.

Also, Upside the Head can keep Shulkie's +2 attack from Superhuman Strength on the board. (If the enemy's already stunned, her Superhuman Strength isn't discarded.)

Great Responsibility preps you for Gamma Slam.

Generation X fetches Gamma Slam or a well-timed Split Personality.

If you're a stickler on 40 cards, the Chance Encounters and Cypher can be excised.